To determine if a single dose of dexamethasone (5 mg) administered in the first 12 hours
following a potentially traumatic event alters a) cortisol and FKBP5 RNA the next day in the
periphery measured in saliva; b) FKBP5 methylation by 1 month; c) executive functioning and
emotion regulation functioning; d) psychophysiological (heart rate, respiration, skin
conductance) in response cued reminders of the trauma; e) enhances the likelihood of
remission of PTSD symptom severity.
Phase:
Phase 1
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health