Dexamethasone and Wound Healing After Thyroid Surgery
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
Dexamethasone is a potent glucocorticoid with analgesic and anti-emetic effects [1-3].
Perioperative single-dose dexamethasone therapy has been used for several purposes: to reduce
post-operative nausea and vomiting (PONV), pain and sore throat. There are also some reports
on beneficial effects of less cardiac arrhythmia, improved appetite and less edema from
glucocorticoids. Preoperative small dose of dexamethasone was reported to prevent reversal
laryngeal nerve injury and improve voice quality after thyroid surgery. While accepted wildly
in clinical anesthesia practice, the immune-press related potential risks of side effects
associated with dexamethasone, such as delayed wound healing, infection, as well as effects
on blood sugar, make the use of perioperative single dose of glucocorticoid controversial.
The effect of perioperative dexamethasone on wound healing varied with different types of
surgery. The present study will observe the effect of dexamethasone on the safety of thyroid
surgery.