Dexamethasone Treatment of Congenital Adrenal Hyperplasia
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if dexamethasone given at night is a more effective
treatment for congenital adrenal hyperplasia in young children than standard three times per
day hydrocortisone. Our hypothesis is that nocturnal dexamethasone will lead to more
efficient suppression of the hypothalamic-pituitary-adrenal axis. We performed a cross-over
trial comparing hormonal control during two 24-hour hospitalizations, one on hydrocortisone
and one on nocturnal dexamethasone.
Phase:
Phase 2
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital