This is a single-center, prospective, randomized, controlled (crossover) clinical study
designed to investigate the specific dose-response impact of insulin infusion rate (IIR) on
blood glucose levels during a pancreatic clamp study in the setting of dexamethasone-induced
insulin resistance. The investigators will recruit participants with a history of
overweight/obesity but no history of prediabetes or diabetes. Participants will be rendered
temporarily insulin resistant by taking seven doses of dexamethasone. They will then undergo
two pancreatic clamp procedures in which individualized basal IIR are identified, followed in
one by maintenance of basal IIR (maintenance hyperinsulinemia, MH) and in the other by a
stepped decline in IIR (reduction toward euinsulinemia, RE). In both clamps the investigators
will closely monitor plasma glucose and various metabolic parameters. The primary outcome
will be the absolute and relative changes in steady-state plasma glucose levels at each
stepped decline in IIR.
Phase:
Phase 1
Details
Lead Sponsor:
Columbia University
Collaborators:
Albert Einstein College of Medicine National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)