Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery
Status:
Terminated
Trial end date:
2018-12-26
Target enrollment:
Participant gender:
Summary
Delirium is a common complication in elderly patients after surgery. And its occurrence is
associated with worse outcomes. The causes of delirium are multifactorial but may include
pain, stress response and inflammation. Dexamethasone is commonly used to prevent the
occurrence of postoperative nausea and vomiting. In a randomized controlled trial, small-dose
dexamethasone (8 mg) administered before anesthesia induction improved the quality of
recovery in patients after cardiac surgery. Flurbiprofen axetil is commonly used to improve
postoperative analgesia while decreasing the requirement of opioids. In a randomized trial of
the investigators, combined use of flurbiprofen axetil with sufentanil for postoperative
analgesia reduced delirium in elderly patients after orthopedic surgery. The purpose of this
2 plus 2 factorial randomized controlled trial is to test the hypothesis that combined use of
dexamethasone and flurbiprofen axetil may reduce delirium in elderly patients after lung
cancer surgery.