Development of a Pharmacodynamic Model for Propofol in Older Adults
Status:
Not yet recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
The goal of this pharmacodynamic study is to develop a model for Propofol administration for
older adults (>65 years). The main objective is to create a model based on a new
pharmacodynamic parameter, derived from frontal electroencephalogram (EEG), to admininster
Propofol in older adults. With this new model, the investigators aim to:
- Evaluate the relationship between the plasmatic concentration, described by the Eleveld
pharmacokinetic model, versus the effect of the drug represented with a new parameter
derived from the intraoperative frontal EEG.
- To validate the predictive ability of Eleveld's pharmacokinetic-pharmacodynamic model,
based on the bispectral index (BIS), compared to the new model based on a parameter
derived from intraoperative frontal EEG.
Participants will be asked to answer preoperative questionnaires, receive a Propofol
intravenous infusion concomitantly with continuous BIS and EEG monitoring, and to be
evaluated for clinical sings of loss and return of consciousness.