Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance
Status:
Not yet recruiting
Trial end date:
2024-04-01
Target enrollment:
Participant gender:
Summary
In kidney transplantation, donor selection is based in part on the assessment of the
functional capacity of the kidneys. For this purpose, it is recommended to measure the
glomerular filtration rate (GFR) by a reference technique. To estimate GFR, several
approaches are possible depending on the type of measurement (urinary or plasma) and the
marker (exogenous or endogenous) used. Among these methods, the measurement of inulin
clearance has long been considered the reference method. The occurrence of anaphylactic
reactions led to its withdrawal from the market. Iohexol, an iodinated contrast agent, has
characteristics similar to inulin. It is eliminated by glomerular filtration and its
biological determination is simple.
Nevertheless, the techniques currently used to calculate plasma clearance of Iohexol have
been imperfectly validated and are not always easy to implement in practice. We propose to
develop a Bayesian estimator for estimating Iohexol clearance applied to a population of
healthy subjects, representative of potential kidney donors.