Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
The investigators objectives were developing mini dose five-drug cocktail regimen to evaluate
potential drug-drug interactions associated with use of a cocktail of caffeine, losartan,
omeprazole, dextromethorphan, and midazolam for simultaneous assessment of CYP1A2, CYP2C9,
CYP2C19, CYP2D6, and CYP3A activities.