Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

• Status: Unknown status
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Southern California Institute for Research and Education
• Collaborators: National Institute of Mental Health (NIMH); University of California, Irvine
• Treatments: Dexmedetomidine; Ketamine; Nitrous Oxide; Propofol

Criteria

Inclusion Criteria:

• Healthy adults.

• Between the ages of 18 and 35.

Exclusion Criteria:

• Pregnancy.

• Left-handed.

• Unusual facial anatomy.

• History of esophageal reflux.

• Respiratory problems.

• Central nervous system disorders.

• Cardiovascular problems.

• Kidney disease.

• Diabetes.

• History of Substance abuse.

• History of adverse anesthetic reactions.

• Hepatitis.

• Failure to pass MRI screening questionnaire.

• Fear of small-enclosed spaces.

• Mental illness.

• Non-native English speakers.