Desflurane Versus Propofol Anesthesia for Off-Pump CABG

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to prove if anesthesia maintained with the inhaled volatile anesthetic desflurane is superior to the intravenously applied propofol anesthesia in off-pump coronary artery bypass grafting (OP-CABG) surgery as measured by following parameters:

1. hemodynamic parameters during and after the operation,

2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital stay,

3. release of heart muscle injury markers in response to surgery and intraoperative ischaemia,

4. inflammatory response to the operation.

We suspect that insufflation anesthesia with desflurane may be superior to intravenous anesthesia with propofol.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Gdansk
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• Patients with coronary artery disease qualified for CABG off-pump surgery

• Elective surgery

• Signed informed consent

Exclusion Criteria:

• Left ventricle ejection fraction < 30%

• Serum creatinine > 2 mg/dL

• Emergency surgery

• Denied consent