Desflurane Versus Propofol Anesthesia for Off-Pump CABG
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to prove if anesthesia maintained with the inhaled volatile
anesthetic desflurane is superior to the intravenously applied propofol anesthesia in
off-pump coronary artery bypass grafting (OP-CABG) surgery as measured by following
parameters:
1. hemodynamic parameters during and after the operation,
2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital
stay,
3. release of heart muscle injury markers in response to surgery and intraoperative
ischaemia,
4. inflammatory response to the operation.
We suspect that insufflation anesthesia with desflurane may be superior to intravenous
anesthesia with propofol.