Overview

Desflurane Preconditioning in Hepatectomies

Status:
Completed
Trial end date:
2018-06-30
Target enrollment:
0
Participant gender:
All
Summary
Hepatectomies are considered as operations of high bleeding risk. The history of massive hemorrhage in liver surgery led to the emergence of techniques to control excessive blood loss. These techniques temporarily occlude the blood vessels that supply liver (the Pringle Maneuver) limiting subsequent losses. However, this leads to the ischemia - reperfusion injury impairing liver function. Research points to methods targeting on tempering reperfusion pathophysiology. Volatile anesthetics have been used for pharmacological preconditioning and proved to protect against organ damage. The aim of this study was to investigate the potential beneficial effect of desflurane on ischemia-reperfusion injury of the liver. Patients presenting for elective hepatectomy were randomized equally into two groups. The Control Group received no pharmacological preconditioning and the Desflurane Group received pharmacological preconditioning with Desflurane before induction of ischemia.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Aristotle University Of Thessaloniki
Treatments:
Desflurane
Isoflurane
Criteria
Inclusion Criteria:

- hepatectomy of at least two segments

Exclusion Criteria:

- Hepatitis B, C or HIV infection

- liver cirrhosis

- autoimmune disease, inflammatory bowel disease

- pregnancy

- prior additional ablation therapies (cryosurgery or radiofrequency)

- liver resections without inflow occlusion