Given that LEO 80185 gel takes effect in the upper layer of the skin, it is important to
compare and examine the amount of the drug in the upper layer of the skin with that of
Dovobet® Ointment. Therefore, a dermatopharmacokinetic study will be conducted in healty
adult male volunteers to evaluate pharmacokinetics of LEO 80185 gel and Dovobet® Ointment in
the stratum corneum. In this trial, a single application of LEO 80185 gel and Dovobet®
ointment will be applied to multiple test sites on the back of healthy Japanese male adults
and the trial is designed to compare the amount of each of the active ingredients at steady
state or close-to-steady state between LEO 80185 gel and Dovobet® Ointment. The amount of
calcipotriol and betamethasone dipropionate in the stratum corneum will be assessed by use of
tape stripping.