Dental Biofilm Control During Orthodontic Treatment
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Orthodontic appliances can affect changes in the relationships of members of the oral
microbiome. Microbiome imbalance can result in oral infections and complicate treatment. The
focus is on the microbiological profile of dental biofilm and its control. The effects of
metals released by corrosion of alloys for oral use on the microbiome and the extent to which
they modify the effectiveness of gingivitis therapy by mechanical and chemical control of
biofilm will be investigated. Early and late colonizers of the tooth surface will be
analyzed. The condition of gingiva will be assessed, and the results will show the specifics
of biofilm and gingiva exposed and unexposed, and differences in the response of individual
bacteria to therapy. Molecular biology techniques will be used to quantify the total
bacterial biomass (16s rRNA) and the proportion of specific bacterial species within the
dental biofilm.