This is a feasibility pilot study to evaluate the impact of local delivery of Yamani-15/5
(combination of L-Lactic acid 15% and D-Gluconic acid 5%) on vascular calcification of lower
extremities in patients with severe peripheral arterial disease (PAD) who were deemed to have
unreconstructable arterial disease and who have already been scheduled to undergo limb
amputation (below knee or above knee amputation).