This research study is being done to determine the safety and tolerability of increasing
doses of defibrotide within a single patient with sinusoidal obstructive syndrome
(SOS)/veno-occlusive disease (VOD) after hematopoietic cell transplantation (HCT) associated
with either kidney and/or lung impairment that has not obtained a complete response (CR) or
progressed in severity with standard doses of defibrotide.