Trial summary: deep neuromuscular block is proposed as a technique to improve operative
conditions for laparoscopy. Early clinical data would suggest that there may also be patient
benefits beyond the operative period related to lower intra-abdominal pressure, and improved
surgical exposure. In order to safely conduct deep neuromuscular blockade, it is essential to
use Sugammadex to reverse the neuromuscular block. Conventional practice is to provide
moderate neuromuscular block and reverse with neostigmine. It is not possible to safely
reverse deep neuromuscular block using neostogmine, as the majority of block must have worn
off for neostigmine to be effective. in order to identify whether deep neuromuscular block
improves quality of recovery after surgery, the investigators will conduct a randomised trial
of deep versus moderate neuromuscular block, whilst minimising variance in other anaesthetic
techniques and drugs used. the outcome measured will be the post-operative quality of
recovery over multiple time periods using the Postoperative Quality of Recovery Scale
(PostopQRS). 350 patients will be enrolled over 4 centres.
Phase:
Phase 4
Details
Lead Sponsor:
University of Melbourne
Collaborators:
Melbourne Health Northpark Private Hospital Northpark Private hospital (Healthscope) Peter MacCallum Cancer Centre, Australia Royal Hospital For Women The Royal Womens Hospital Melbourne Victorian Comprehensive Cancer Centre Peter Macallum hospital)