Overview

Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Status:
Completed
Trial end date:
2020-03-31
Target enrollment:
Participant gender:
Summary
This phase II/III trial is studying the side effects and how well giving dasatinib together with combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia (ALL). Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving dasatinib together with combination chemotherapy may kill more cancer cells.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
National Cancer Institute (NCI)
Treatments:
6-Mercaptopurine
Asparaginase
BB 1101
Calcium
Calcium, Dietary
Cortisol succinate
Cortisone
Cortisone acetate
Cyclophosphamide
Cytarabine
Dasatinib
Daunorubicin
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Etoposide
Etoposide phosphate
Folic Acid
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Ifosfamide
Isophosphamide mustard
Lenograstim
Leucovorin
Levoleucovorin
Mercaptopurine
Methotrexate
Methylprednisolone
Methylprednisolone Acetate
Methylprednisolone Hemisuccinate
Pegaspargase
Podophyllotoxin
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Prednisone
Vincristine