Overview

Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hannover Medical School
Collaborator:
Novartis
Treatments:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Cefuroxime
Cefuroxime axetil
Daptomycin
Criteria
Inclusion Criteria:

- age between 18-80

- written informed consent (IC)

Exclusion Criteria:

- pregnant and lactating women

- patients operated for a transplantation

- patients with a increased myopathy risk

- patients with a creatinine clearance < 30ml/min; patients on hemodialysis

- patients after a previous sternotomy

- treatment with any antibiotics 14 days prior study start

- treatment with Daptomycin or Cefuroxime within 3 month prior study start