This is two-way crossover study to compare pharmacokinetic (PK) of daprodustat 2 milligram
(mg) versus 4 mg tablets and food effect on the PK of daprodustat following single oral doses
in healthy Japanese male subjects. This study will be conducted in two parts. Part 1 is the
bioequivalence part in which subjects will receive single dose of 2 tablets of 2 mg
daprodustat and single dose of 1 tablet of 4 mg daprodustat in crossover manner. Part 2 is
Food effect part. In this part, subjects will receive single dose of 4 mg daprodustat tablet
in fasting and fed state in a crossover manner. There will 5-day wash-out period between each
intervention period. There will be approximately 52 subjects in Part 1 and 12 subjects in
Part 2. The study will last for 6 weeks.