Daily Four Times or Two Times Usage of PPI and Amoxicillin for the First or Second Line H. Pylori Eradication
Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
The hypothesis and plan of the current study are:
1. One induction phase of high dose PPI before eradication will increase intragastric pH
and induce H. pylori into an active replicative status. Active replicative status will
enhance the bactericidal effect of amoxicillin. Rabeprazole (20 mg) four times per day
(qid) for 3 days will be used for induction in this study.
2. High dose PPI will provide adequate plasma concentration irrespective of the CYP2C19
genotype of the population. Here rabeprazole (20 mg) qid will be applied as high dose
PPI.
3. High frequent amoxicillin usage (500 mg, qid) will maintain plasma concentration above
the MIC. Amoxicillin (500 mg) qid will be described for total 14 days.
4. In the rescue therapy, add levofloxacin on high dose dual therapy will increase the
eradication rate than single high dose dual therapy. A combination of levofloxacin and
high dose dual therapy will also have a better eradication rate than the common used
levofloxacin based triple therapy.