Dacomitinib in Lung Cancer With Uncommon EGFR Mutations
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
This is a single center and exploratory study, aiming to analyze the efficacy and safety of
dacomitinib-a pan-HER and irreversible TKI in subjects with diagnosed stage IIIB/IV or
recurrent NSCLC. All subjects will have tumors that test positive for at least one uncommon
EGFR activating mutation (do not have drug-resistant pattern, e.g. 20 insertion or 20T790M).
All patients will be of histo- and/or cytopathology confirmed. Determination of the EGFR
mutation type will be performed in the pathological department of Shanghai Chest Hospital.
Both ARMS method or targeted sequencing are acceptable. It is not acceptable for subjects
with the presence of the exon 20T790M mutation or insertion together with either EGFR
activating mutations (exon 19 deletion or the L858R mutation in exon 21) or uncommon EGFR
mutations. 10ml peripheral blood must be available for concomitant study. All eligible
subjects must have adequate renal, hepatic, and hematologic function, as defined in
"inclusion criteria".
Patients will receive continuous oral therapy with the study drugs (dacomitinib 45 mg) until
progressive disease as defined by RECIST version 1.1 or judged by investigator that the
patient no longer derives clinical benefit from study treatment. At the time of progression
and removal from study treatment, the subject may receive any regulatory approved therapy at
the judgment of the investigator. Timely and complete disease assessments in this study are
important. Every effort should be made to ensure disease assessments performed as scheduled
to prevent the introduction of bias into the assessment of efficacy. Failure to perform any
of the required disease assessments will result in the inability to determine disease status
for that time point. Frequent off schedule or incomplete disease assessments have the
potential to weaken the study conclusion.
Subjects who have progressive disease per RECIST version 1.1 confirmed by the investigator
believes it is in their best interest to continue on their study therapy, will be allowed to
continue on their therapy with or without local therapy (e.g. surgical removal and/or
radiation of a single lesion), at the discretion of the investigator until any alternate or
additional systemic anti-cancer therapy regimen is implemented. The subsequent new cancer
therapy (including, for systemic therapy, drugs administered, date of initiation and
discontinuation of each drug) and OS will be recorded. Each subject will be followed for
survival status and subsequent cancer therapies up to 48 months from the date of first
dosing. This data may be collected from subjects by telephone, and if collected should be
entered into the CRF.