Four periods of oral dosing following overnight fasting (1. known metabolic probe drug
cocktail consisting of caffeine, diclofenac, esomeprazole, metoprolol, midazolam; 2.
dabigatran + cocktail; 3. dabigatran alone; 4. clarithromycin 3 days + cocktail +
dabigatran). Blood samples collected for pharmacokinetics over 24 h. Washout between periods.
Adverse events, haematology and clinical chemistry recorded.