DREAM: Does Inhaled Fluticasone REsult in Obstructive Sleep Apnea Manifestations?
Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
This study is being conducted to find out if the use of inhaled corticosteroids has an affect
on upper airway (UAW) collapsibility and sleep apnea risk. An inhaled corticosteroid is a
common asthma controller medication like Flovent. Sleep apnea or sleep deprived breathing
(SDB) is when someone stops breathing for a short period of time during sleep. For some
reason, people with asthma have more sleep apnea and upper airway (UAW) collapsibility
(weakness) than the general population. There are many possible reasons for this and one
might be related to the use of inhaled corticosteroids.
The overall hypothesis of this study is to determine whether inhaled fluticasone propionate
(FP) increases UAW collapsibility and to assess tongue (genioglossus muscle) dysfunction as a
potential underlying mechanism.
Phase:
N/A
Details
Lead Sponsor:
University of Wisconsin, Madison
Collaborators:
Brigham and Women's Hospital National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health (NIH) University of California, San Diego University of California, San Francisco