DPP-4 Inhibitors and Acute Myocardial Infarction:Effects on Platelet Function
Status:
Completed
Trial end date:
2020-02-28
Target enrollment:
Participant gender:
Summary
Cardiovascular events are the main cause of mortality in diabetic patients ,on the other
hand,during an acute myocardial infarction(AMI),hyperglycemia increases mortality and is
related to different pathophysiologic processes.
More important evidence regarding the effect of glycemic control on AMI patients prognosis is
contradictory,and the potential benefits of dipeptidyl peptidase-4 inhibitors(DPP4-i) in this
setting is unknown.
The aim of this study is to assess the presence of pleiotropic effects of DPP4-i(sitagliptin
or saxagliptin) and their relationship with glycemic control during in-hospital phase of AMI.