Overview

DPP-4 Inhibitor and Serum BNP Level of Diabetic Patients With Congestive Heart Failure

Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
0
Participant gender:
All
Summary
We thought to investigate the influence of DPP-4 inhibitor on the serum BNP level of diabetic patients with congestive heart failure. This study consists of two protocols. In the first protocol, diabetic patients with high level of serum BNP (100-2000 pg/ml) receiving outpatient treatment with any type of DPP-4 inhibitor at our institution will be enrolled. After baseline data collection, DPP-4 inhibitor will be suspended for one month and serum BNP will be measured. The DPP-4 inhibitor will be resumed and after another month, serum BNP will be measured again. In the other protocol, diabetic patients who were hospitalized due to heart failure were enrolled. DPP-4 inhibitor will be started (if the patient is not taking a DPP-4 inhibitor) or suspended (if the patient is taking a DPP-4 inhibitor) after stabilization of heart failure, and serum BNP will be measured before and after the drug administration or suspension.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mitsui Memorial Hospital
Collaborator:
Mitsukoshi Health and Welfare Foundation
Treatments:
Dipeptidyl-Peptidase IV Inhibitors
Criteria
Outpatient arm

Inclusion Criteria:

- Type 2 diabetes patient with congestive heart failure under treatment with DPP-4
inhibitor (sitagliptin, vildagliptin, alogliptin, linagliptin, teneligliptin,
anagliptin or saxagliptin) .

- High serum BNP (100-2000pg/ml).

- Patients who have given informed consent to participation in the study.

Exclusion Criteria:

- HbA1c over 9.0%.

- Patients who changed medication within 1 months before inclusion.

- Judged as ineligible by clinical investigators.

Hospitalization arm

Inclusion Criteria:

- Type 2 diabetes patient who were hospitalized for congestive heart failure.

- Patients who have given informed consent to participation in the study.

Exclusion Criteria:

- Patients on insulin therapy.

- Judged as ineligible by clinical investigators.