Various chemical modifications of allergens have been attempted to enhance efficacy, improve
safety, and foster compliance with IT. These approaches have been unsuccessful - in that the
allergenicity and immunogenicity have either decreased, or increased in tandem, with no
resultant efficacy: safety benefit ratio. This study utilizes an adjuvant approach in which
synthetic immunostimulatory DNA is conjugated to ragweed allergen in an attempt to modulate
both the clinical and immunologic allergic response to ragweed exposure in ragweed-allergic
patients with seasonal rhinitis.