DAPSONE GEL7.5%Versus Trichloroacetic Acid 20% ON ACNE VULGARIS

• Status: Not yet recruiting
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Acne vulgaris, a chronic inflammatory skin disorder, is one of the most prevalent diseases that effects more than 80% of the population worldwide (1). A variety of factors such as genetics, hormones, infections, as well as environmental factors have been identified as the causes of acne development (2). Acne usually generates as a result of blockage in the pilosebaceous unit (including hair follicle, hair shaft, and sebaceous gland) due to the over-produced sebum by sebaceous gland, which further triggers the excessive proliferation of the bacterium Propionibacterium acnes (P. Acnes). (3)

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Dapsone

Criteria

Inclusion Criteria:

• Both males and females will be included.

• Patients older than 12 years of age.

• Patients with mild and moderate AV.

• Patients had not received any topical or systemic treatment for AV during the previous 2 weeks

Exclusion Criteria:

• Severe acne.

• Patients under treatment with contraceptive pills or any kind of systemic or topic acne medication (isotretinoin, antibiotics, topical products).

• History of hypertrophic/keloid scar formation.

• Pregnancy, breast feeding.

• Recurrent herpes infection.