D-dimer to Establish Duration of Anticoagulation After Venous Thromboembolism

• Status: Completed
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The optimal duration of oral anticoagulant treatment in patients with idiopathic venous thromboembolism is still uncertain. The present study addresses the possible role of the D-dimer test in assessing the need for continuation of anticoagulation.The study aims at assessing whether D-dimer assay may have a role in guiding the duration of anticoagulation in these patients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna; St. Orsola Hospital
• Treatments: Anticoagulants; Fibrin fragment D; Vitamin K

Criteria

Inclusion Criteria:

• Age > 18 years

• After a first documented idiopathic proximal deep vein thrombosis and/or pulmonary embolism

• After at least 3 months of oral anticoagulation

• After written informed consent

Exclusion Criteria:

• If the Venous thromboembolism occurred:

• during pregnancy or puerperium

• after recent (i.e. within three months) fracture or plaster casting of a leg,

• after immobilization with confinement to bed for three consecutive days

• after surgery with general anesthesia lasting longer than 30 minutes

• Patients with:

• active cancer

• antiphospholipid antibody syndrome

• antithrombin deficiency

• serious liver disease or renal insufficiency (creatininemia > 2 mg/dL),

• other indications for anticoagulation or contraindications for this treatment

• limited life expectation

• Patients who live too far from the clinical center