Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Untreated Autoimmune hepatitis (AIH) is a progressive disease. Mainstay of treatment are
corticosteroids (CS). In addition to being ineffective a substantial minority of cases,
corticosteroid side-effects hamper effective therapy in another subgroup. Alternative options
for induction of remission are limited. There are reports of successful salvage therapy with
Cyclosporine-A (CsA) in steroid refractory cases. In addition, open-labeled studies have
shown efficacy of Cyclosporine-A in treatment-naive AIH patients. There are no studies
comparing CsA and CS in a head to head trial. The investigators aim to assess the efficacy
and tolerability of CsA directly to the CS for induction of remission in treatment-naive AIH
patients.