Cycloserine rTMS Plasticity Augmentation

• Status: Completed
• Trial end date: 2018-11-07
• Target enrollment: 0
• Participant gender: All

Summary

Transcranial magnetic stimulation (rTMS) is an investigational and therapeutic modality that impacts the connection strength between neurons by delivering patterned energy. In response to this patterned energy neurons fire and adapt by changing their connection strengths. This change in connection strengths is believed to be the underlying mechanism whereby this intervention has therapeutic benefit for this intervention in conditions such as depression. The purpose of this study is to test a means of enhancing the effect of rTMS using a medication (cycloserine) that has been shown to augment and stabilize activity dependent neuronal changes. The investigators wish to use the motor system, where the associated muscle response to brain stimulation can be measured, to probe activity dependent changes in connection strength between neurons.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Calgary
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

1. Healthy individuals 18-60 years of age.

Exclusion Criteria:

1. Pregnancy

2. Lactation

3. Epilepsy

4. Previous Stroke

5. Current Renal Disease

6. Current Liver Disease

7. Current Alcohol Use Disorder

8. Inability to refrain from alcohol use for 24 hours prior to each session and following each session.

9. Allergy to antibiotics

10. Use of isoniazid, ethionamide or bupropion

11. Current psychiatric concerns

12. History of bipolar disorder

13. Family history of bipolar disorder

14. Intracranial implants (dental implants are not an exclusion criteria)