Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving low doses of chemotherapy, such as cyclophosphamide, before a donor bone
marrow transplant helps stop the growth of abnormal cells. It also stops the patient's immune
system from rejecting the donor's bone marrow. The donated bone marrow stem cells may replace
the patient's immune system and help destroy any remaining abnormal cells. Sometimes the
transplanted cells from a donor can also make an immune response against the body's normal
cells. Giving cyclosporine and methotrexate before or after transplant may stop this from
happening.
PURPOSE: This phase I trial is studying the side effects and best dose of cyclophosphamide in
treating patients who are undergoing a donor bone marrow transplant for Fanconi's anemia.