Cyclophosphamide for Hematopoietic Stem Cell Mobilization in Patients With a Hematologic Malignancy
Status:
Completed
Trial end date:
2020-09-01
Target enrollment:
Participant gender:
Summary
No prospective randomized trials have evaluated the most efficacious dose of cyclophosphamide
to mobilize autologous stem cells. We previously demonstrated that the time to collection of
autologous hematopoietic stem cells is 10-12 days following the one dose of cyclophosphamide
and daily G-CSF (granulocyte-colony stimulating factor).9 This prospective randomized trial
is designed to determine if a lower dose of cyclophosphamide (1.5 gm/m2) will be as
efficacious as the intermediate dose (3 gm/m2), based on cell number collected, number of
apheresis required and resource utilization.