Cycled Testosterone Administration During Pulmonary Rehabilitation in Early Stage COPD
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the
airways and/or damage to the lungs which leads to progressive impairment in airflow and the
ability to breathe. COPD affects 6 to 20% of the US population and is among the leading
causes for mortality in men and women. While COPD is principally a pathology of the airway,
skeletal muscle wasting is a widely recognized comorbidity contributing to frequent and
expensive hospital visits.
Hospital readmission rates among COPD patients are high and the majority of the readmissions
are considered preventable. The reasons COPD patients lose muscle are still poorly understood
although reduced pulmonary function has been associated with reduced testosterone levels.
Muscle building treatments, including testosterone therapy, with and without exercise, have
consistently been shown to promote improvements in body composition, exercise capacity, and
health related quality of life of COPD patients.
The overall goal of this investigation is to provide an effective long-term treatment
strategy that prevents the advancement of COPD in men and women through a safe, cycled
administration of testosterone during the early stages of disease.