15% of diabetics have a diabetic foot (DF) in their lives associated with a risk of
amputation and mortality two times greater than that of a diabetic population without DF.
Predicting the occurrence of an DF is limited and only the occurrence of a diabetic wound up
involved assessment and treatment. Our team is behind the discovery of the Pressure-Induced
Vasodilation (PIV) first observed in healthy subjects after local application of a gradual
pressure on the skin leading to cutaneous vasodilation at the application of pressure. This
gain in blood flow delays the onset of ischemia. However the involvement of PIV in the DF,
which is also a pressure-induced skin lesion, remains to be demonstrated in diabetic
subjects. The main objective of this study is to show that PIV, a functional examination of
the cutaneous microcirculation we developed, is altered in the presence of DF, taking into
account the influence of age and neuropathy.
Phase:
N/A
Details
Lead Sponsor:
Hospices Civils de Lyon
Treatments:
EMLA Lidocaine Lidocaine, Prilocaine Drug Combination Prilocaine