Curcumin for the Chemoprevention of Colorectal Cancer
Status:
Completed
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
Specific Aims:
- To determine if curcuminoids modulate cellular proliferation as measured by
proliferating cell nuclear antigen (PCNA) in the colorectal mucosa of subjects with
previously resected adenomatous colonic polyps.
Hypothesis: Curcuminoids decrease cellular proliferation in the colorectal mucosa of
subjects with previously resected sporadic adenomatous colonic polyps.
- To determine if curcuminoids modulate apoptosis, as measured by TUNEL assay, in the
colorectal mucosa of subjects with previously resected adenomatous colonic polyps.
Hypothesis: Curcuminoids increase apoptosis in colorectal mucosa of subjects with previously
resected sporadic adenomatous colonic polyps.
- To determine if curcuminoids modulate COX-2 expression as measured by
immunohistochemical assays in subjects with previously resected adenomatous colonic
polyps
Hypothesis: Curcuminoids decrease colorectal mucosa COX-2 expression in subjects with
previously resected sporadic adenomatous colonic polyps.
- To determine if curcuminoids modulate COX-2 activity as measured by urinary eicosanoids
Hypothesis: Curcuminoids decrease concentrations of urinary eicosanoids.