Cryotherapy in Treating Patients With Primary Stage I Non-Small Cell Lung Cancer or Lung Metastasis

• Status: Active, not recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Cryotherapy kills tumor cells by freezing them. Giving cryotherapy before surgery may kill more tumor cells.

PURPOSE: This phase I trial is studying how well cryotherapy works in treating patients with primary stage I non-small cell lung cancer or lung metastasis.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barbara Ann Karmanos Cancer Institute
• Collaborator: National Cancer Institute (NCI)
• Treatments: Prednisone

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed (by percutaneous transthoracic needle biopsy or transbronchial biopsy) diagnosis of 1 the following:

• Non-small cell lung carcinoma

• Stage I disease

• Primary disease

• No primary lung metastatic disease, satellite lesions of the chest, mediastinal lymph nodes > 1.5 cm, hepatic or adrenal masses by the PET scan or the CT scan

• Metastatic cancer to the lung

• Must have a definitive cancer diagnosis with the primary tumor under local control and no metastatic disease other than to the lung

• Solitary or multiple (≤ 3) peripheral lung lesions

• No chemotherapy since the new metastatic lesion appeared

• Measurable disease, defined as 1 lesion unidimensionally measured ≤ 3.0 cm by conventional CT scan techniques

• Must be registered with the Clinical Trials office at the Karmanos Cancer Center/Wayne State University

• Must be a candidate for a thoracotomy

• No evidence of cerebral disease or metastatic disease of the brain

PATIENT CHARACTERISTICS:

• Neutrophil count > 1,500/mm^3

• Platelet count > 75,000/mm^3

• PT and PTT normal

• FEV_1 > 1.0 L/sec

• Diffusing capacity ≥ 30%

• Not pregnant or nursing

• No other uncontrolled or concurrent illnesses including, but not limited to, any of the following conditions:

• Active infection

• Heart failure

• Unstable angina

• Cardiac dysrhythmia

• Psychiatric illness or a social situation that would limit compliance with the study requirements

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No prior radiation therapy or chemotherapy for these particular tumors

• No concurrent aspirin or other platelet-inhibiting drugs (e.g., coumadin or heparin)

• No other concurrent experimental studies