Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist
Status:
Completed
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
Traditionally, the use of GnRH-a suppression was considered essential for adequate
endometrial hormonal modulation in cryopreserved-thawed embryo transfer cycles. Several
studies, however, have questioned its necessity for controlled endometrial preparation. Using
a high dose of estradiol from day 1 of the cycle will suppress the gonadotroph, preventing
folliculogenesis and excessive secretion of LH, allowing adequate endometrial preparation
without GnRH-a.
Phase:
Phase 3
Details
Lead Sponsor:
Cairo University
Collaborators:
Kamal Shaeer center of infertility Nile Ivf Center, Cairo, Egypt