Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
Status:
Recruiting
Trial end date:
2029-06-01
Target enrollment:
Participant gender:
Summary
"Wait & see" is currently the standard of care of recently diagnosed desmoid tumors (DT). In
case of progression or symptomatic disease, medical therapy is nowadays widely used including
chemotherapy.
Cryoablation has proven to be beneficial for the treatment of large, progressive and
symptomatic DT.
This randomized phase II trial aims to compare cryoablation versus medical therapy in DT
patients progressing after the "wait & see" period. Moreover, a cross-over design has been
anticipated to allow all patients to undergo cryoablation if necessary.