Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Case Western Reserve University
• Treatments: Gabapentin; gamma-Aminobutyric Acid; Memantine

Criteria

Inclusion Criteria:

• Adult (18 years or older) males or females with acquired nystagmus that is degrading their vision

Exclusion Criteria:

• Pregnant women

• Individuals who cannot describe their visual symptoms, cooperate with testing, or give informed consent

• Individuals with intolerance of gabapentin or memantine