Creatine Use and Muscle Stretching in Peripheral Artery Disease
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
To utilize near-infrared spectroscopy to investigate if the research device, which induces
muscle stretching, and creatine loading impact submaximal exercise performance in aged and
PAD patients. Near-infrared spectroscopy (NIRS)-derived tissue oxygenation responses will be
obtained during device placement (muscle stretch) and during a walking test (i.e., six-minute
walk test). Muscle oxygenation at rest and during device placement will be assessed with
Magnetic Resonance Imaging. It is hypothesized that the stretching protocol will improve both
NIRS-derived tissue oxygenation and magnetic resonance-derived muscle oxygenation and that
creatine supplementation will further improve phosphorus metabolite muscle performance. All
patients will undergo either 4 weeks of stretch training with- or- without creatine
supplementation according to previously defined creatine guidelines.