Creatine Augmentation in Veterans With SSRI-Resistant Major Depression
Status:
Withdrawn
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether creatine will be helpful as an adjunctive
treatment for treatment-resistant major depressive disorder (MDD) in female and male
Veterans. We hypothesize that Veterans receiving creatine will show decreased depressive
symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS). We will also
use 31-Phosphorus Magnetic Resonance Spectroscopy (31-P MRS) brain scans to compare levels of
neurochemicals related to energy metabolism in the brain, before-and-after treatment with
creatine, and between healthy controls and MDD participants.