Cranial Blocks for Postoperative Anesthesia

• Status: Enrolling by invitation
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study compares the standard of care to the standard of care plus the administration of bupivacaine or liposomal bupivacaine in patients receiving craniotomies.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pennsylvania
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• ≥18 years of age

• Need for elective supratentorial craniotomy

• Preoperative GCS > 13

Exclusion Criteria:

• Preoperative GCS ≤ 13

• Child (<18 years of age)

• Inability to understand or use the visual analog scale (VAS)

• Proven or suspected allergy to local anesthetics

• Craniotomy incision extending beyond the field of the block

• Patients chronically (more than 2 wk) treated with narcotic medications

• Previous scalp incision

• Bilateral craniotomies

• Allergies to local anesthetics

• GCS verbal score < 4 after extubation

• Patients whose surgeries extend past 6 hours (will be placed on standard of care and removed from study)

• Patients currently on ergot-type oxytoxic drugs, MAOIs, or certain antidepressants

• Lactating Mothers