This prospective, randomized, open-label, multi-center interventional study is designed to
compare the safety and efficacy of two LMWH dosing protocols in patients admitted to the
University of Iowa Hospitals with COVID-19 who meet the modified ISTH Overt DIC criteria
score ≥3. Patients will be randomized to standard prophylactic dose LMWH (standard of care
arm) or intermediate-dose LMWH (intervention arm).