Cosopt Versus Xalacom

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus the LTFC given once every morning following a run-in period with timolol maleate given twice daily.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pharmaceutical Research Network
• Treatments: Dorzolamide; Latanoprost; Maleic acid; Timolol

Criteria

Inclusion Criteria:

• adults with primary open-angle or pigment-dispersion glaucoma, or ocular hypertension

• at baseline the intraocular pressure should be 20 to 32 mm Hg inclusive at 08:00 measurement (Visit 2) after dosing with timolol the evening before

• the intraocular pressure should be 32 mm Hg or less at all the time points in both eyes at Visit 2

• visual acuity should be 6/60 or better in the study eye(s)

Exclusion Criteria:

• any anticipated change in systemic hypotensive therapy during the trial

• use of any corticosteroids by any route for more than two weeks during the study

• contraindications to study medicines