Corticosteroid and Repeated Dextrose Hydro-dissection for Carpal Tunnel Syndrome Patients
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Carpal tunnel syndrome (CTS) is the most prevalent peripheral nerve entrapment of upper limb.
Typical symptoms comprise pain, numbness or tingling of the thumb and index, middle or ring
fingers. Thumb weakness and decreased grip strength can occur in the later stage. Currently
treatments included physical modalities (low power laser, transcutaneous electrical nerve
stimulation, ultrasound), medication, splinting, injection and surgery. Ultrasound guided
intracarpal hydro-dissection of median nerve had been proposed based on its accurate
localization, while the injectates were diverse. Corticosteroid has been widely used for CTS
for decades. However, growing evidences suggested that 5% dextrose, normal saline, platelet
rich plasma injection also have therapeutic effects on alleviating CTS symptoms. Among the
injectates, a single 5% dextrose injection could be considered as a substitute of
corticosteroid based on its long term effect up to six months. However, the clinical efficacy
of 5% dextrose injection has not validated by the further study. The investigators aim to
compare the therapeutic effect of 5% dextrose injection with corticosteroid injection in
patients with CTS, up to 12 weeks follow up.