Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Osmotherapy has been used as the medical treatment for brain edema and intracranial
hypertension in critically brain injured patients. Measurement of serum osmolality during
osmotherapy is of clinical importance to determine clinical efficacy, adjust dosage and avoid
side effect. Serum osmolality is often measured in laboratory by cryoscopic technique as the
reference method. However, in clinical setting, routine measurement of serum osmolality is
not feasible at bedside, either in intensive care unit (ICU) or neurosurgical ward.
Therefore, clinicians usually estimate serum osmolality by using equations derived from serum
osmoles that can be measured by bedside blood gas analysis or routine laboratory chemical
analysis, such as sodium, potassium, urea, and glucose. In present study, mannitol or
hypertonic saline will be used in patients after craniotomy, and serum osmolality will be
measured before and during drug infusion. Investigators hypothesize that the correlation of
measured and calculated serum osmolality is better during infusion of hypertonic saline than
mannitol.