Correlation Between the Interstitial and Arterial Glucose in Post Surgery Patients
Status:
Completed
Trial end date:
2005-04-01
Target enrollment:
Participant gender:
Summary
The EU funded project CLINICIP (Closed Loop Insulin Infusion for Critically Ill Patients)
aims to develop a low-risk monitoring and control device which allows maintaining metabolic
control in intensive care units. A system will be developed comprising three subsystems: a
body interface for the delivery of biofluids, biosensors for the determination of glucose
concentration in these biofluids and an adaptive control algorithm that generates advice and
thus represents a decision support system with respect to insulin infusion rate to establish
glycaemic control in critically ill patients. Within a closed loop system, intensified
insulin treatment will make use of the calculations leading to external regulation of
glucose.
It is the aim of this study to evaluate the correlation between arterial blood glucose
concentrations and interstitial fluid glucose concentrations in post surgery patients in the
Intensive Care Unit (ICU). Interstitial fluid glucose concentrations are based on
microdialysis in subcutaneous adipose tissue and calculated using the ionic reference
technique.