Objective: To study whether an administration of corifollitropin alpha modifies the
follicular cohort, measured by Follicular Output Rate (FORT), compared to human menopausal
gonadotropin (HMG), in infertile patients undergoing in vitro fertilisation (IVF).
M/M: 306 infertile patients undergoing in vitro fertilisation (IVF). Ovarian stimulation
protocol will be performed with a single dose of 100 μg (<60kg) or 150 μg (≥60kg)
corifollitropin alpha in group 1 (n=147), and 150-300 IU/day human menopausal gonadotropin
(HMG) according to age, antimullerian hormone (AMH) level and antral follicle count (AFC) in
group 2 (n=150).
Moreover, FORT will be calculated as the ratio of pre-ovulatory follicle (16-22 mm in
diameter) count on day of HCG×100/small antral follicle (3-8 mm) count at baseline.