Cooperation of Insulin and GLP-1 on Myocardial Glucose Uptake
Status:
Completed
Trial end date:
2017-09-08
Target enrollment:
Participant gender:
Summary
27 Type 2 diabetic subjects (HbA1c 7.5 - 9.5%) currently treated with diet and exercise alone
or with oral antidiabetic agents will be randomly assigned to one of three treatment groups:
insulin detemir, liraglutide, or liraglutide plus detemir (9 subjects per group), on a
background of metformin 2000 mg per day. After 3 months' treatment, PET measurements of
myocardial fuel selection will take place, under fasting conditions in the morning following
that day's treatment injection(s).