Conversion to Sirolimus: Effects in Cytomegalovirus Infection Recurrence
Status:
Unknown status
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
Cytomegalovirus is the most important opportunistic infection after kidney transplant, with
increased in mortality, morbidity and higher costs of transplantation. Despite the favorable
efficacy (lower acute rejection) results of the most worldwide used regime, tacrolimus,
mycophenolate and prednisone, or the investigators local common regimen, tacrolimus,
azathioprine and prednisone, this combinations are associated with higher incidence of
cytomegalovirus infection, disease and recurrence.
Namely, sirolimus use is associated with decreased risk of cytomegalovirus infection/disease,
and there is not a prospective cohort to evaluate the conversion to sirolimus efficacy to
decrease the cytomegalovirus infection recurrence.
Given this, the investigators propose a study of their own initiative that attends local
needs: evaluate the conversion to sirolimus efficacy in decrease the cytomegalovirus
recurrence after kidney transplant.